Non-internalizing monoclonal antibodies are suitable candidates for I radioimmunotherapy of small-volume peritoneal carcinomatosis
نویسندگان
چکیده
1 IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, F-34298, France; INSERM, U896, Montpellier, F-34298, France; Université Montpellier1, Montpellier, F34298, France; CRLC Val d’Aurelle Paul Lamarque, Montpellier, F-34298, France; 2 CRLC Val d’Aurelle-Paul Lamarque, F-34298 Montpellier, France; 3 Service de Médecine Nucléaire, CHU de Nîmes, Nîmes F-30029, France; 4 Direction de la Radioprotection de l’Homme, Institut de Radioprotection et de Sûreté Nucléaire, Fontenay-aux-Roses, F-92262 France;
منابع مشابه
radioimmunotherapy of small-volume peritoneal carcinomatosis
We have previously shown that, monoclonal antibodies (mAbs) labeled with the Auger electron emitter I are more in vitro, 125 cytotoxic if they remain at the cell surface and do not internalize in the cytoplasm. Here, we assessed the biological efficiency in vivo of internalizing and non internalizing I-labeled mAbs for the treatment of small solid tumors. 125
متن کاملNoninternalizing monoclonal antibodies are suitable candidates for 125I radioimmunotherapy of small-volume peritoneal carcinomatosis.
UNLABELLED We have previously shown that, in vitro, monoclonal antibodies (mAbs) labeled with the Auger electron emitter (125)I are more cytotoxic if they remain at the cell surface and do not internalize in the cytoplasm. Here, we assessed the in vivo biologic efficiency of internalizing and noninternalizing (125)I-labeled mAbs for the treatment of small solid tumors. METHODS Swiss nude mice...
متن کاملBrief intraperitoneal radioimmunotherapy of small peritoneal carcinomatosis using high activities of noninternalizing I - labeled 125 monoclonal antibodies
We assessed the efficiency and toxicity of brief-intraperitoneal radioimmunotherapy (Bip-RIT) using high activities of I-labeled 125 monoclonal antibodies (mAbs) in the treatment of small volume peritoneal carcinomatosis.
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BACKGROUND AND PURPOSE We assessed the contribution of antibody internalization in the efficacy and toxicity of intraperitoneal α-radioimmunotherapy (RIT) of small volume carcinomatosis using (212)Pb-labeled monoclonal antibodies (mAbs) that target HER2 (internalizing) or CEA (non-internalizing) receptors. MATERIALS AND METHODS Athymic nude mice bearing 2-3 mm intraperitoneal tumor xenografts...
متن کاملBrief intraperitoneal radioimmunotherapy of small peritoneal carcinomatosis using high activities of noninternalizing 125I-labeled monoclonal antibodies.
UNLABELLED We assessed the efficiency and toxicity of brief intraperitoneal radioimmunotherapy using high activities of (125)I-labeled monoclonal antibody (mAb) in the treatment of small-volume peritoneal carcinomatosis. METHODS Brief intraperitoneal radioimmunotherapy consisted of a 185-MBq (740 MBq/mg) intraperitoneal injection of (125)I-35A7 (an anti-carcinoembryonic antigen mAb) into athy...
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